Synthetic Vasomotion Prescreening

Thank you for your potential interest in the Synthetic Vasomotion study, sponsored by generous donors of IHMC, and in partnership with Applied Cognition.

Time Commitment: 3 study visits to IHMC, approximately 2 hours each (Mon, Wed, Fri)

Participants may also take the device home for one night of use, but not all participants will be asked to do so. Self-administration: approximately 10 minutes.

Compensation: 

Compensation will be provided for participation.

Study Description:

This study investigates how intermittent hypercapnia (low-level carbon dioxide exposure), guided breathing, noninvasive vagus nerve stimulation (nVNS), and wearable physiological monitoring influences sleep, autonomic regulation, and brain-related physiology in adults with early-stage Parkinson’s disease, as well as healthy older adults. Participants will wear the provided noninvasive monitoring devices that measure sleep, breathing, heart rate, movement, and brain activity during visit, as well as overnight monitoring procedures.

Eligibility (Parkinson’s Disease Group):
1. Adults aged 60–80 years at the time of enrollment.
2. Clinical diagnosis of early-stage Parkinson’s disease who are not receiving levodopa or
other dopaminergic medication.
3. Hoehn and Yahr stage I.
4. English-speaking and able to provide informed consent and complete study procedures
and questionnaires administered in English.
5. Cognitively able to participate in study procedures, as determined by investigator
assessment and/or optional cognitive screening measures, when administered.
6. Willing and able to comply with all study visits and procedures.
7. Able to tolerate wearing the Applied Cognition GF Monitor, physiological monitoring
equipment, face mask, and noninvasive vagus nerve stimulation (nVNS) device for the

Eligibility (Age-Matched Healthy Control Group):
1. Adults aged 60–80 years at the time of enrollment.
2. No known diagnosis of Parkinson’s disease or other major neurodegenerative disorder.
3. English-speaking and able to provide informed consent and complete study procedures
and questionnaires administered in English.
4. Cognitively able to participate in study procedures, as determined by investigator
assessment and/or optional cognitive screening measures, when administered.
5. Willing and able to comply with all study visits and procedures.
6. Able to tolerate wearing the Applied Cognition GF Monitor, physiological monitoring
equipment, face mask, and noninvasive vagus nerve stimulation (nVNS) device for the

duration of study procedures.