Evening Lectures - Ocala

Dom D’Agostino

THE TALK: Achieving Therapeutic Ketosis

February 29, 2024


The science and application of ketogenic diets and ketone metabolic therapy is developing rapidly and moving into human clinical trials for a diverse range of applications. The presentation will focus on past, present, and emerging research on nutritional and supplemental approaches to achieve therapeutic ketosis. These metabolic-based therapies are successfully used to treat neurological disorders, and many common diseases that are linked to poor metabolic health. Metabolic-based therapies, including diet and supplementation, can alter systemic physiology, brain metabolism, cellular bioenergetics, and even gene expression. In addition, the lecture will cover important cardiometabolic biomarkers that should be measured and discussed with your doctor, but that are not typically associated with routine exams. These biomarkers and measurement tools help to advance personalized medicine and are important for enhancing longevity and metabolic health. Normal ranges of these biomarkers will be discussed as well as methods to achieve ideal ranges that are associated with disease prevention and metabolic health optimization.


Dr. D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. D’Agostino received his B.S. in Nutritional Science and Biological Sciences in 1998 at Rutgers University before receiving a Predoctoral Fellowship in Neuroscience and Physiology at Rutgers and the University of Medicine and Dentistry of New Jersey (UMDNJ) in 1999. In 2004 Dr. D’Agostino did a postdoctoral fellowship in Neuroscience at the Boonshoft School of Medicine at Wright State University in Ohio before moving to USF Tampa in 2006. In addition to his teaching responsibilities, his laboratory develops and tests nutritional strategies and metabolic-based therapies for neurological disorders, cancer and metabolic optimization. He is conducting basic science research and human clinical trials. He has a personal interest in environmental medicine and methods to enhance safety and physiological resilience of military personnel and astronauts in extreme environments. His research metabolic control and neuroscience is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and nonprofit foundations.

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